Hydrogen Peroxide in Industry and Medicine

Peroxygen compounds, Block, S., 1991, in Disinfection, Sterilization and Preservation, 4th edition, S. Block (ed.), Lea and Febiger, Philadelphia, p167-181 Approved use of hydrogen peroxide in aseptic packaging processes, processing of cheese and cheese-related products (part 133), eggs and egg products (part 160) and as an antimicrobial in whey processing, 1981, FDA (Food and Drug Administration) Federal regulation; 46(6)

Effect of hot water and hydrogen peroxide treatments on survival of salmonella and microbial quality of whole and fresh-cut cantaloupe, Ukuku DO, Pilizota V, Sapers GM. J Food Prot. 2004 Mar; 67(3) p432-7.

Decontamination of broilers with hydrogen peroxide stabilized with glycerol during processing, Wagenaar CL, Snijders JM., Int J Food Microbiol. 2004 Mar 1;91(2):205-8.

Remediation of the Wells G & H Superfund Site, Woburn, Massachusetts, Bair ES, Metheny MA., Ground Water. 2002 Nov-Dec;40(6):657-68.

Ozonation and H2O2/UV treatment of clofibric acid in water: a kinetic investigation, Andreozzi R, Caprio V, Marotta R, Radovnikovic A. J Hazard Mater. 2003 Oct 31;103(3):233-46.

Removal of trichloroethylene from waste gases via the peroxone process, Van Craeynest K, Dewulf J, Vandeburie S, Van Langenhove H. Water Sci Technol. 2003;48(3):65-72.

Combined application of simulated reuse and quantitative carrier tests to assess high-level disinfection: experiments with an accelerated hydrogen peroxide-based formulation, Sattar SA, Adegbunrin O, Ramirez J., Am J Infect Control. 2002 Dec;30(8):449-57.

A decontamination process to remove metals and stabilise Montreal sewage sludge, Mercier G, Blais JF, Hammy F, Lounes M, Sasseville JL., ScientificWorldJournal. 2002 Apr 26;2:1121-6.

Improved combined chemical and biological treatments of olive oil mill wastewaters, Bressan M, Liberatore L, d'Alessandro N, Tonucci L, Belli C, Ranalli G., J Agric Food Chem. 2004 Mar 10;52(5):1228-33.

New applications of chemical germicides: hydrogen peroxide, Klapes, N.A., 1990, in Program and Abstracts of the ASM (American Society for Microbiology) International Symposium on Chemical Germicides; 20 p14-15

Peroxide as a remedial agent, Love, I.N., 1988, JAMA; 10(9) p1279

Antitumor effects of hydrogen peroxide in vivo, Nathan, C.F., Cohn, Z.A., 1981, Journal of Experimental Medicine; 154 p1539-1553

Efficacy of vaporized hydrogen peroxide against exotic animal viruses, Heckert, R.A., Best, M., Jordan, L.T., et al., 1997, Applied and Environmental Microbiology; 63(10) p3916-3918

Killing of blood-stage murine malaria parasites by hydrogen peroxide, Dockrell, H.M., Playfair, J.H., 1983, Infection and Immunity; p456-459

Efficacy of a fluoridated hydrogen peroxide-based mouthrinse for the treatment of gingivitis: a randomized clinical trial, Hasturk H, Nunn M, Warbington M, Van Dyke TE., J Periodontol. 2004 Jan;75(1):57-65.

Effective control of dental chair unit waterline biofilm and marked reduction of bacterial contamination of output water using two peroxide-based disinfectants, Tuttlebee CM, O'Donnell MJ, Keane CT, Russell RJ, Sullivan DJ, Falkiner F, Coleman DC., J Hosp Infect. 2002 Nov;52(3):192-205.

Hydrogen Peroxide In the Immune System

Hydrogen peroxide mediated killing of bacteria, Clifford, D., Repine, J.E., 1982, Molecular and Cellular Biochemistry; 49 p143-149

Oxygen intermediates are required for interferon activation of NK cells, Helfand, S.L., Werkmeister, J., Pross, H., Roder, J.C., 1983, Journal of Interferon Research; 3(2) p143-151

Induction of interferon (gamma) production by human natural killer cells stimulated by hydrogen peroxide, Munakata, T., Semba, U., Shibuya, Y. et al., 1985, The Journal of Immunology; 134(4) p2449-2455

H2O2 release from human granulocytes during phagocytosis, Root, R.K., Metcalf, J., Oshino, N., Chance, B., 1975, The Journal of Clinical Investigation; 55 p945-95

Adverse Effects of Chlorine

Chlorine poisoning at the swimming pool revisited; anatomy of two minidisasters. Decker, W.J., 1988, Veterinary and Human Toxicology; 30(6) p584-585

Explosion risk from swimming pool chlorinators and review of chlorine toxicity. Martinez, T.T., Long, C., 1995, Journal of Toxicology; 33(4) p349-354

Swimming pool chlorination: A health hazard? Aiking, H., Van Acker, M.B., Scholten, R.J., et al., 1994, Toxicology Letters; 72(1-3) p375-380

Illnesses in relation to swimming pool visits – conclusions of a survey. Botzenhart, K., Kampe, A.A., Streib, R., 1988, Zentralbl Bakteriol Mikrobiol Hyg; 186(2) p118-137

Irritating effects of disinfection by-products in swimming pools. Erdinger, L., Kirsch, F., Sonntag, H.G., 1998, Zentralbl Hyg Umweltmed; 20(5-6) p491-503

Influence of free residual chlorine on the skin in swimming pools. Takayanagi, Y., Nagaya, Y., Matsumoto, Y., Ohashi, M., 1994, Japanese Journal of Clinical Opthalmology; 48(5) p843-846

Allergic contact dermatitis from chlorinated swimming pool water. Sasseville, D., Geoffrion, G., Lowry, R.N., 1999, Contact Dermatitis; 41(6) p347-348

Erythema multiforme following swimming in a chlorinated pool. Leung, A., 1985, Journal of the National Medical Association; 77(1) p13

Swimming and the risk of cutaneous melanoma. Nelemans, P.J., Rampen, F.H., Kiemeney, L.A. et al., 1994, Melanoma Research; 4(5) p281-286

Reactivation of oral-lingual herpes by chlorinated swimming pool water. Detweiler, M.B, Barelli, A., 1997, Cutis; 59(5) p260

Chlorine inhalation toxicity from vapors generated by swimming pool chlorinator tablets. Wood, B.R, Colombo, J.L., Benson, B.E., 1987, Pediatrics; 79(3) p427-430

Factors associated with respiratory problems in swimmers. Potts, J., 1996, Sports Medicine; 21(4) p256-261

Increased sensitization to aeroallergens in competitive swimmers. Zwick, H., Popp, W., Budk, G., et al., 1990, Lung; 168(2) p111-115

Swimming-induced asthma. Fjellbirkeland, L., Gulsvik, A., Walloe, A., 1995, Tidsskr Nor Laegeforen; 115(17) p2051-2053

Hazards of chlorine to asthmatic patients. Rothery, S.P., 1991, British Journal of General Practice; 41(342) p39

Evaluation of mutagenic and carcinogenic properties of brominated and chlorinated acetonitriles: by-products of chlorination. Bull, R.J., Meier, J.R., Robinson, M., et al., 1985, Fundamental of Applied Toxicology; 5(6) p1065-1074

Genotoxic properties of haloacetonitriles: drinking water by-products of chlorine disinfection. Daniel, F.B., Schenck, K.M., Mattox, J.K., et al., 1986, Fundamental of Applied Toxicology; 6(3) p447-453

Analysis of in vivo and in vitro DNA strand breaks from trihalomethane exposure, Geter DR, Chang LW, Hanley NM, Ross MK, Pegram RA, DeAngelo AB., J Carcinog. 2004 Feb 17;3(1):2.

Assessment of the carcinogenic potential of chlorinated water; Experimental studies of chlorine, chloramines and trihalomethanes. Dunnick, J.K., Melnick, R.L., 1993, Journal of the Cancer Institute; 85(10) p817-822

Exposure to chlorination by-products from hot water uses. Weisel, C.P., Chen, W.J., 1994, Risk Analyses; 14(1) p101-106

Plasma chloroform concentration in swimmers using indoor swimming pools. Aggazzotti, G., Fantuzzi, G., tartoni, P.L., Predieri, G., 1990, Archives of Environmental Health; 45(3) p175-179

Estimates of cancer risk from chloroform exposure during showering in Taiwan. Kuo, H.W., Chiang, T.F., Lo, I.I., et al., 1998, Science of the Total Environment; 218(1) p1-7

Uptake of chlorination disinfection by-products; a review and a discussion of its implications for exposure assessment in epidemiological studies. Nieuwenhuijsen, M.J., Toledano, M.B., Elliott, P., 2000, Journal of Expository Annals of Environmental Epidemiology; 10(6) p586-599

Trihalomethane concentrations in swimmers' and bath attendants' blood and urine after swimming or working in indorr swimming pools. Cammann, K., Hubner, K., 1995, Archives of Environmental Health; 50(1) p61-65

Blood and breath analyses as biological indicators of exposure to trihalomethanes in indoor swimming pools. Aggazzotti, G., Fantuzzi, G., Righi, E., Predieri, G., 1998, Science of the Total Environment; 217(1-2)

Alveolar breath sampling and analysis to assess trihalomethane exposures during competitive swimming training. Lindstrom, A.B., Pleil, J.D., Berkoff, D.C., 1997, Environmental Health Perspectives; 105(6) p636-642

Safe drinking water: a public health challenge. Wigle, D.T., 1998, Chronic Disease Canada; 19(3) p103-107

Chemical contamination of water supplies. Shy, C.M., 1985, Environmental Health Perspectives; 62 p399-406

Chlorination, chlorination by-products and cancer: a meta-analysis. Morris, R.D., Audet, A.M., Angelillo, I.F., et al., 1992, American Journal of Public Health; 82(7) p955-963

Drinking water chlorination by-products and cancer. Koivusalo, M., Vartiainen, T., 1997, Environmental Health Reviews; 12(2) p81-90

Chlorination of drinking water and cancer incidence. Suarez-Varela, M.M., Llopis Gonzalez, A., et al., 1994, Journal of Environmental Pathology Toxicology and Oncology; 13(1) p39-41

Water chlorination: essential process or cancer hazard? Bull, R.J., Birnbaum, L.S., Rose, J.B., et al., 1995, Fundamentals of Applied Toxicology; 28(2) p155-166

Drinking water and cancer. Cantor, K.P., 1997, Cancer Causes Control; 8(3) p292-308

Drinking water and cancer. Morris, R.D., 1995, Environmental Health Perspectives; 103(8) p225-231

Chlorination of drinking water and cancer mortality in Taiwan. Yang, C.Y., Chiu, H.F., Cheng, M.F., Tsai, S.S., 1998, Environmental Research; 78(1) p1-6

Drinking water chlorination and cancer – a historical cohort study in Finland. Koivusalo, M., Pukkala, E., Vartiainen, T. et al., 1997, Cancer Causes Control; 8(2) p192-200

The association of drinking water source and chlorination by-products with cancer incidence among postmenopausal women in Iowa: a prospective cohort study. Doyle, T.J., Zheng, W., Cerhan, J.R., et al., 1997, American Journal of Public Health; 87(7) p1168-1176

Drinking water mutagenicity and leukemia, lymphomas and cancers of the liver, pancreas and soft tissue. Koivusalo, M., Vartiainen, T., Hakulinen, T. et al., 1995, Archives of Environmental Health; 50(4) p264-276

Cancer of the pancreas and drinking water: a population-based case-control study in Washington County, Maryland. Ijsselmuiden, C.B., Gaydos, C., Feighner, B., et al., 1992, American Journal of Epidemiology; 136(7) p836-842

Drinking water mutagenicity and urinary tract cancers: a population-based case-control study in Finland. Koivusalo, M., Hakulinen, T., Vartianen, T., et al., 1998, American Journal of Epidemiology; 148(7) P704-712

Case-control study of bladder cancer and chlorination by-products in treated water (Ontario Canada). King, W.D., Marrett, L.D., 1996, Cancer Causes Control; 7(6) p596-604

Bladder cancer in Massachusetts related to chlorinated and chloraminated drinking water: a case-control study. Zierler, S., Feingold, L., Danley, R.A., Craun, G., 1992, Selected papers from the First Annual Meeting of the International Society for Environmental Epidemiology, September 13-15, 1989, Science of the Total Environment; 127(1-2) p135-136

Bladder cancer, drinking water source and tap water consumption: a case-control study. Cantor, K.P., Hoover, R., Hartge, P., et al., 1992, Selected papers from the First Annual Meeting of the International Society for Environmental Epidemiology, September 13-15, 1989, Science of the Total Environment; 127(1-2) p135

Drinking water source and chlorination byproducts. I. Risk of bladder cancer. Cantor, K.P., Lynch, C.F., Hildesheim, M.E., et al., 1998, Epidemiology; 9(1) p21-28

Drinking water source and chlorination byproducts. II. Risk of colon and rectal cancers. Hildesheim, M.E., Cantor, K.P., Lynch, C.F., et al., 1998, Epidemiology; 9(1) p29-35

Drinking water source and chlorination byproducts in Iowa. III. Risk of Brain Cancer. Cantor, K.P., Lynch, C.F., Hildesheim, M.E., et al., 1999, American Journal of Epidemiology; 150(6) p552-560

Meta-analysis of studies on individual consumption of chlorinated drinking water and bladder cancer, Villanueva CM, Fernandez F, Malats N, Grimalt JO, Kogevinas M., J Epidemiol Community Health. 2003 Mar;57(3):166-73.

Disinfection byproducts and bladder cancer: a pooled analysis, Villanueva CM, Cantor KP, Cordier S, Jaakkola JJ, King WD, Lynch CF, Porru S, Kogevinas M., Epidemiology. 2004 May;15(3):357-67.